London, May 23 (ANI): Scientists have shed new light into the mechanism by which bone cells produce new bone in response to mechanical stresses, such as exercise.
The findings lay a path for developing new strategies for treating diseases characterized by low bone density, such as osteoporosis in adults and osteogenesis imperfecta in children.
The research team was led by Matthew Warman at the Orthopedic Research Laboratories (ORL) in the Department of Orthopedic Surgery at Children’s Hospital Boston.
Warman and his colleagues developed mouse models to better understand the role of a gene called Lrp5 in bone growth.
While the gene’s exact functions remain unclear, Lrp5 is believed to help mature bone cells called osteocytes respond to changes in mechanical load and call for the production of more bone when needed.