Successfully Developed New Assessment Of Myocarditis For The First Time

by CMC Seoul Administrator ,  CMC Seoul | 2012-07-17

Researchers in Korea developed MRI assessment method with magneto-fluorescent nanoparticles (MNPs) to diagnose myocarditis for the first time.    
Myocarditis is defined as inflammation of heart muscle which leads to heart failure or sudden death. To date, myocarditis was diagnosed inefficiently with traditional diagnostic methodologies such as invasive endomyocardial biopsy (EMB) and various examinations with low accuracy. Now, with new assessment method, it is expected to diagnose myocarditis more accurately and patients can receive proper treatment accordingly.
A team at the Seoul St. Mary’s Hospital led by Prof. Kiyuk Chang (Ms. Hyo Eun Park) of Cardiovascular department conducted the joint research with Dr. Kwan Soo Hong and Dr. Hyeyoung Moon from Korea Basic Science Institute and presented noninvasive assessment to visualize myocardial inflammatory cellular infiltrates by cardiovascular magnetic resonance (CMR) imaging in a rat model of experimental autoimmune myocarditis (EAM) with the administration of magneto-fluorescent nanoparticles (MNPs).

The team administered MNPs to EAM and control rats. After analyzing the movement of nanoparticle in the experimental group, it was found that these particles were selectively absorbed into inflammatory cells including macrophage within inflamed myocardial area and induced negative contrast as the inflamed area to be seen black. A biopsy result also confirmed that inflammatory areas were infiltrated with fluorescent materials.


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