Stem cells taken from patients or donors can treat people with enlarged hearts safely and with similar effectiveness, according to late-breaking clinical trial results presented at the American Heart Association’s Scientific Sessions 2012.
The Comparison of Allogeneic vs. Autologous Bone Marrow Derived Mesenchymal Stem Cells Delivered by Transendocardial Injection in Patients with Ischemic Cardiomyopathy trial (POISEIDON) is also published in the Journal of the American Medical Association.
“This cell therapy clearly had some clinical benefits and the mesenchymal stem cells from donors were just as safe as those from the recipient,” said Joshua Hare, M.D., the lead study author. “Even in patients who had heart attacks several decades before treatment, both donor and recipient stem cells reduced the amount of scarring substantially, by one-third.”
The mesenchymal stem cells (MSCs) — unique because the body’s protective antibodies don’t attack them — are found in adults’ bone marrow.