A study result suggests that gastric cancer stem cell causes recurrence of gastric cancer and lowers the survival rate of gastric cancer patients.
Dr. Han Hong Lee and Dr. Hae Myung Jeon’s research team of Department of Gastrointestinal Surgery in Uijeongbu and Seoul St. Mary’s Hospital, Catholic University of Korea have announced that gastric cancer patients with cancer stem cell are likely to face recurrence or death within 5 years.
Out of a total 406 patients who underwent gastric cancer surgery at Uijeongbu St. Mary’s Hospital from 2001 to 2005, 100 gastric cancer patients who received curative gastrectomy followed by adjuvant chemotherapy were enrolled in the study to analyze the expression of cancer stem cells.
CD 133 (Pentaspan transmembrane glycoprotein) expression was analyzed to verify the cancer stem cells.(Fig1) The rate of positive CD133 expression was 23%.