Researchers and specialists from the Hospital Universitari i Politècnic La Fe and the Universitat Politècnica de València have developed a new mathematical model to help in the selection of embryos for transfer in fertility treatments.
According to the recent study, published in the journal Mathematical and Computer Modelling, the model is especially useful for embryo transfers. Most benefits will be for intermediate quality embryos on the second day after fertilization, when it is possible to estimate the probability of implantation in the uterus.
When evaluating the quality of embryos, researchers say two morphological variables are analyzed - cell number and the degree of the embryo. The best embryos have four cells grade one, being the most likely to result in a pregnancy. Researchers explain their model would help embryologists in embryo selection. Some embryos that do not meet these requirements may also lead to a pregnancy, yet, in the fertilization process, embryos that posses these features are not always obtained.
In order to use the model, the specialists would observe all the embryos with an inverted microscope and would value the number of cells and degree of each one. With the help of these variables, they select the embryos with a higher implantation rate. Then the specialists would obtain the EQI of all the embryos transferred and with this and the woman's age they could predict the likelihood of pregnancy.
Although there are other tools to assist embryo selection before transfer, researchers mention their predictive ability is inferior to that developed in this model of embryo implantation. Researchers point out “The model presented is faster, more efficient and accurate, as it allows a better selection of the embryos with the higher chance of implanting in the uterus".