The CCSVI-Center Frankfurt/ Germany was founded in 2010, motivated by Prof. Zamboni's work regarding the potential vascular origin of multiple sclerosis and the demand by MS-patients for treatment.
Because of the novelty of CCSVI, with few studies being available to assess long term outcomes, our primary goal at the CCSVI-Center Frankfurt is expressed by "primum nil nocere" - avoiding harm to patient as our primary objective.
To achieve this goal we have formed collaboration between experts in the field of diagnostic imaging and vascular intervention who each are linked into an international network of specialists. This guarantees the highest level of proficiency in the diagnosis and treatment of CCSVI, the avoidance of negative side effects and complications and the participation in the rapid exchange of expert knowledge.
The close spatial relationship between demyelization plaques and venous vessels on which CCSVI based, was postulated before 1980s as also the link between venous outflows disorders in the brain and the development back marks of MS.
Multiple sclerosis (MS) has been considered for many years to be an autoimmune disease, but recent research from Italy points out a possible new cause. According to the theory of Prof. Paolo Zamboni, a vascular surgeon from Ferrara, narrowings (stenoses) in jugular veins (neck) or the azygos veins returning the blood from the head to the heart, might be responsible for the development and the symptoms of MS (Multiple sclerosis).
The blood vessels constriction prevents blood flowing quickly enough (so-called reflux, where the blood vessels does not work properly and the blood flows into the brain again), with the consequence that iron is deposited in the brain (it could be seemed as white plaques visible on the MRI scan) causing autoimmune inflammation damaging the protective myelin nerve coating in the spinal cord and in the brain.
This condition has become known as "CCSVI”: chronic cerebro-spinal venous insufficiency.
Widening of the stenotic (narrowed) veins increases the blood flow through them, thus, relieving the back-pressure and eliminating the inflammation, which is causing the damage to the brain, the spinal cord and protective myelin.
CCSVI investigation and diagnosis at CCSVI-Center (Frankfurt/Germany):
MRV-Screening - CCSVI Diagnostics following a modified and advanced Haacke Protocol.
In order to diagnose the CCSVI, CCSVI-Center in Frankfurt uses non-invasive or mini-invasive CCSVI investigations methods. Our experience and our collaboration with the vendors of medical equipment and medical scientists around the world helped us to improve the CCSVI Diagnosis protocols, in order to provide reliable and safe diagnostic for our patients.
Identification of CCSVI according to Zamboni is based on three methods:
Ultrasound examination (only head and neck)
- The limitation of ultrasound is that it cannot assess the intrathoracic and abdominal venous system.
But it provides real-time information about blood flow dynamics, which is necessary to assess reflux in the lower internal jugular vein segment, that is important for the blood flow from the brain to the heart.
- MR-Venography (head, neck, thorax and abdomen - Haacke protocol)
Improved Haacke Protocol by CCSVI-Center in Frankfurt
MR venography showing with color coding demonstrating focal stenosis of the upper internal jugular veins (IJV).
We have implemented the following improvements for the Haacke protocol:
- Combination of fast non breath-hold mr-venography (MRV) followed by slower breath-hold MRV for the lower neck and upper thoracic venous system
- Flow-visualization along the internal jugular veins (IJV)
- Flow visualization of the azygos vein-superior vena cava junction
- Improved multi breath-hold single-volume equilibrium MRV of the thoracic and abdomino-pelvic venous system Examples of the respective improvements are show below.
The Haacke MR-protocol has been established as the standard for MR-venography and flow measurements in the work-up of CCSVI. It has, however, several drawbacks. Since MR-venography is carried out without breath holding and without cardiac gating, the azygos vein, that drains the blood from the spinal cord, cannot be depicted with sufficient accuracy on MRI
- Catheter venography under fluoroscopy
Catheter venography or venogram, as a specialized form of angiography, is a medical imaging technique used to image the inside of blood vessels. This is traditionally done by injecting a contrast agent into the blood vessel and imaging with an X-Ray based technology such as fluoroscopy.
During catheter venography, a long, thin, flexible plastic tube (catheter) is inserted into the body, usually through a vein in the groin. The catheter is then threaded through the vascular system to the area requiring examination. A contrast dye is injected through the catheter and a rapid series of x-rays is taken, offering a detailed look at the specific blood vessels under the question.
Catheter Venography showing the mild midlevel stenosis
The costs for CCSVI investigations, including coordination, mediation and English language support depend on the art of the necessary investigation, additional packages and start from € 1050 to € 2500.
Safety of the Treatment
Over the past 18 months we have successfully treated well over 400 patients, without complications.
Results of CCSVI and Multiple Sclerosis liberation Treatment
||Improvement oft the motoric system /
|Treatment response in
More than 90 % of our patients have an improvement after the treatment.