New ART Technology Identifies Previously Unknown Predictors of Embryo Viability

by Unisense FertiliTech A/S ,  The Sacramento Bee | 2012-09-21

The EmbryoScope® Time-lapse system generates a movie allowing embryologists to monitor various characteristics of the embryo development over the entire incubation period, while maintaining optimum incubation conditions in a state-of-the-art incubator.

According to breakthrough scientific results, embryos which exhibit irregular division patterns have a much lower pregnancy potential. The results were made available online on August 27 in the journal Fertility & Sterility, and confirms the benefits of implementing the EmbryoScope® Time-lapse system from the Danish company Unisense FertiliTech A/S.

A clinical multi-center study from Equipo IVI, Spain, Maigaard clinic and Brædstrup Hospital in Denmark, including a total of 5225 embryos, reports significantly reduced implantation of embryos which have a second division cycle occurring in less than 5 hours (considered direct cleavage), compared  to the implantation probability of "normally" developing embryos. The embryos with a short second division cycle will simply not have enough time for DNA replication, which is a prerequisite for a normal cell division.

Nearly 14% of all examined embryos exhibited this division pattern and according to the study will have a greatly reduced probability of resulting in a viable pregnancy. For both patients and fertility clinics it is important to decrease transfer of embryos with low very low implantation potential. With this new technology, clinics now have objective criteria with which to identify the embryo with a higher chance of implanting allowing more successful single embryo transfer cycles.



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