PRP - Platelet Rich Plasma Cell Therapy - Stem Cell Therapy

 PRP - Platelet Rich Plasma Cell Therapy

PRP - Platelet Rich Plasma Cell Therapy Treatment Abroad



latelet Rich Plasma (PRP) is a break-through therapy process for medical science and is primarily used for stimulating and accelerating bone as well as soft tissue healing. It is actually a new form of biotechnology that focuses on the growing interest worldwide especially in cellular therapy and tissue engineering.

Platelet Rich Plasma Cell therapy has opened the doors for possible treatments especially for people suffering from a variety of musculoskeletal problems or injuries. Although, this form of therapy is fairly new, it holds the key to providing relief from musculoskeletal injury as compared to an open surgery. There are several areas where patients can enjoy benefits and this include lowering of risk of therapy or surgery, lesser healing time, a natural process of healing, and good maintenance of normal biomechanics of the human body.


Platelet Rich Plasma Cells – A Brief Overview

Since the Platelet Rich Plasma (PRP) cell therapy is fairly new, most people are unaware of what it really is and how it works. Some important and interesting facts that will enable the understanding of the PRP include:

  1. Platelet-rich plasma is basically blood plasma, which has been enriched with blood platelets.
  2. Platelet-rich plasma contains a variety of growth factors as well as cytokines, which are responsible for stimulating the healing process of soft tissue and bones.
  3. The most common uses of PRP cell therapy include a variety of medical fields like dentistry, cosmetic surgery, pain management, and sports medicine.
  4. The platelets that have been collected in PRP get activated only when calcium chloride and thrombin are added and this enables tissue repair
  5. There are a variety of growth factors present in platelet-rich plasma (PRP) and that includes:
  1. Platelet-derived growth factor (PDGF): It regulates cell growth as well as division.
  2. Insulin-like growth factor 1 (IGF-1): It is also known as somatomedin C and enables childhood growth
  3. Insulin-like growth factor 2 (IGF-2): It is considered to be a key fetal growth factor
  4. Transforming growth factor beta (TGF-β): It regulates key cellular activities
  5. Connective tissue growth factor (CTGF): It is responsible for stimulating tissue wound repair and skeletal development.
  6. Fibroblast growth factor (FGFs): They aid in embryonic development and wound healing
  7. Epidermal growth factor (EGF): It is responsible for stimulating cell growth
  8. Vascular endothelial growth factor (VEGF): It is also known as vascular permeability factor (VPF) and is responsible for restoring oxygen supply to tissues during hypoxic conditions.
  9. Keratinocyte growth factor (KGF): It plays a key role in wound healing
  10. Interleukin 8 (IL8): It is considered to be a pro-inflammatory mediator in psoriasis and gingivitis

Laboratory and clinical studies have revealed that when concentration of growth factors in platelet rich plasma is increased then it stimulates the healing process and speeds it up.


How does PRP cell therapy work?

The immediate response of the human body towards any type of soft tissue injury is to deliver platelet cells that have a high concentration of healing and growth factors. The natural healing process of PRP works towards ensuring the body is able to deliver an increased concentration of platelets directly to the injury area or wound. The process for PRP cell therapy works in the following way:

  • A small sample of the patient's blood is drawn out (similar to blood tests) and it is placed in a centrifuge, which spins this blood at a high speed. This process enables the separation of the platelets from other components of the blood.
  • This process is normally executed manually by an experienced lab technician
  • The process produces increased pure concentration of platelets and beneficial blood components
  • These platelets are then injected in or around the wound or point of injury of the said patient
  • The injected PRP significantly strengthens and speeds up the overall healing process
  • Since, the blood used for PRP therapy is that of the patient, hence there is a reduced risk of transmissible infection as well as any type of allergic reaction


Therapeutic potential of platelet rich plasma (PRP) cells

Therapeutic potential of platelet rich plasma (PRP) cells

The therapeutic potential of Platelet Rich Plasma (PRP) cell therapy is quite interesting and can be considered as one of the breakthrough’s in the field of medical science especially when it comes to injury healing. Some of the existing and potential applications of the PRP cells are:


Treatment of Chronic Tendon Injuries

Chronic tendon injuries can come in a variety of forms. Similarly, the healing process of chronic tendon injuries takes place through 3 different phases, which are inflammation, proliferation, and remodeling. Reports have indicated that PRP cells therapy has successfully aided in the healing of supraspinatus tendon (small muscle of the upper back). This is more so because PRP contains several cytokines that help in initiating or accelerating tendon healing. Research has indicated that athletes undergoing treatment for Achilles tendon have experienced faster recovery through Platelet Rich Plasma cell therapy.

Note: The use of Platelet Rich Plasma (PRP) cell therapy for tendon disorders is still under investigation stage and this includes disorders like chronic tendinosis.

Muscle Healing

Muscle injury can take place just about anywhere and anytime, although it is more common in sports and martial arts. Similarly, the process of muscle healing occurs through three overlapping phases, which are inflammation, proliferation, and remodeling.  Healing in a muscle injury depends primarily on local vascularity as well as the regeneration of various intramuscular nerve branches. The good news is that both of these can be enhanced significantly through PRP.

Note: The speed of healing in the various phases will depend on the type and severity of the injury.

Bone Fracture healing

Fractures are one of the most common injuries for athletes or sportsperson. Fractures can also be caused to just about anyone while playing or through an accident. Platelet-rich plasma (PRP) cell therapy is now considered as one of the most common therapies for accelerating spinal fusion and maxillofacial bone-graft healing. PRP is known to enhance bone formation. This is not all as this therapy also has benefits for people suffering from osteoporotic fractures.


Future Prospects

The most obvious question asked by many is, "Will Platelet-rich plasma (PRP) cell therapy aid in Pain Management" in the near future? The truth is that platelet-rich plasma (PRP) has the definite potential to reduce pain and regenerate tissues but the success of a PRP therapy will depend solely on the preparation method as well as PRP composition.


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