Anadolu Medical Center | International Hospital Istanbul

Top Bone Marrow Transplant Package in Istanbul, Turkey

Cayirova Mh., Merkezi Hastanesi, 41420 Istanbul, Turkey

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Treatment :Obesity/Bariatric Surgery

By : Anadolu Medical Center | International Hospital Istanbul

Location : Cayirova Mh., Merkezi Hastanesi Istanbul, Turkey 41420

Focus Area: International Hospital Istanbul | Heart Surgery | Robotic Surgery | Hip Replacement Surgery| Oncology | Cardiac Care | Fertility Treatment | Plastic & Reconstructive Surgery | Orthopedic Surgery | Urology Clinic | Istanbul, Turkey

International Hospital Istanbul Turkey, Anadolu Medical Center, Oncology Cancer Treatment Hospital, Cardiac Care, Robotic Surgery, Robot Asissted Surgery, Urology Surgery, IVF Clinic, Orthopedic Treatment Center, Hip Replacement, Knee Replacement

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What is Bone Marrow and Hematopoietic Stem Cell?

Bone marrow is a soft; sponge like tissue located inside the bone. It contains cells termed hematopoietic or blood making stem cells.

Hematopoietic stem cells may divide to generate more blood making stem cells or develop to create “red blood cells-erythrocytes”, “white blood cells-leukocytes” and “thrombocytes” that join blood circulation. Most of hematopoietic stem cells are found in bone marrow however there are also traces of them in the umbilical cord and blood.

Cells obtained from any of these locations may be used for transplant.

What is Bone Marrow Transplant?

Bone marrow transplant and peripheric blood stem cell transplant is the healing of damaged stem cells using high doses of chemotherapy and/or radiation therapy.

There are three types of transplant:

Autologous transplant: Transplant from patients own stem cells.

Syngeneic transplant: Transplant by acquiring stem cells from identical twins.

Allogeneic transplant: Transplant by acquiring stem cells from siblings or parents. A non-related donor may also be used if suitable.

How is Bone Marrow Transplant Performed?

Transplant from own body fundamentally requires the treatment of illness. For this reason, Patient will be treated in accordance with a method specified by physicians. In the next stage, stem cells are collected and frozen with the help of certain medication.

The dose of medication must be increased in these types of patients. On average patient is given high doses of medication for a week following the collection of healthy stem cells. Healthy hidden stem cells are given back to the patient following high dose of medication treatment. This approach allows the self-repair of stem cells damaged during treatment.

How is Bone Marrow Obtained for Transplant?

Stem cells used in bone marrow transplant are obtained from a liquid centre called marrow. On general terms the procedure of obtaining bone marrow, usually called “harvesting”, is similar in al three types of bone marrow transplant (autologous, allogeneic, syngeneic). During the procedure the donor is either given a sedative general anaesthesia or local anaesthesia resulting in numbness below the waist.

Needles are inserted into the bone marrow of the pelvic bone for extraction. Marrow harvesting takes about one hour.

Harvested bone marrow is processed to remove traces of bone and blood. A preservative may be added to the harvested bone marrow and later frozen to keep the stem cells ready until needed. This method is known as cryopreservation. Stem cells may be kept for long years using the cryopreservation method.

Diseases Treatable with Bone Marrow Transplant

  • Acute Myeloblastic Leukaemia
  • Acute Lymphoblastic Leukaemia
  • Non-Hodgkin’s Lymphoma
  • Hodgkin’s Lymphoma
  • Multiple Myeloma
  • Myelodysplastic Syndrome
  • Chronic Myelocytic Leukaemia
  • Chronic Lymphocytic Leukaemia
  • Aplastic Anaemia
  • Paroxysmal Nocturnal Haemoglobinuria
  • Primary Amyloidosis
  • Solid Cancers: Testicle Cancer, Ovarian Cancer / Ewing Sarcoma
  • Hereditary Diseases: Haemoglobinopathies
  • Autoimmun disease (Scleroderma, Lupus, Rhomateid arthrite)

    Top Bone Marrow Transplant Package in Turkey

Initial Assessment at Anadolu

Initial assessment begins with transplant physician meeting at the bone marrow transplant outpatient clinic. This meeting will involve:

Transplant coordinator nurse giving the patient an orientation tour of the bone marrow transplant department.

The following steps will commence once the form is signed:

1. Forward Planning
Selecting caretaker: A relative or close friend is chosen to help the patient in every sense. The transplant coordinating nurse will train this person on his/her responsibilities.

Living in Istanbul or Kocaeli: Patient will be briefed on the need to live somewhere near to the hospital up to 1- 4 months following the transplant. Transplant team will help to make necessary arrangements.

2. Preparing for Transplant
Choosing donor: Allogeneic Transplantation: The first step for allogeneic transplant is locating a HLA matching sibling or relative.

Examination: Outpatient tests will be performed for 1-2 weeks to determine overall medical condition; additional examinations like bone marrow aspiration, lung x-ray ,

Bone marrow mobilisation procedure will span a 7 to 20 day period depending on the regime.

3. Preparation Regime
Treatment regime duration and components is different for each type of illness and on average continued for 2 to 8 days.

4. Stem Cell Transplant
1 or 2 days after the preparation regime is completed arfempheil stem cell will be infused quite similar to blood transfusion.

Whether autologus or allogeneic all frozen bone marrow or perigherl stem cell collected from the donor will be thawed beside the patient following necessary preparations and administered intravenously through the central catheter.

Bone marrow or perigherl stem cell can be collected transplant dry from donor and given to the pztrent unfrozen. Donor will begin mobilisation regime prior to the transplantation. Bone marrow will be collected on the day of transplantation and administered intravenously without getting frozen.

5. Waiting for Engraftment
Engraftment is the successful incorporation of grafted bone marrow into the body of the host resulting in generation of blood elements. This process takes between 10 to 35 days. Following engraftment patient’s discharge condition and date will be specified depending on factors like infection, intravenous medication and adequate oral nutrition intake.

6. Post-Engraftment Healing
First signs of healing after engraftment will take about 3 months. This period is spent near the hospital in Istanbul or Kocaeli. Patient will be asked to come to the hospital for regular blood tests (weekly or shorter) during this period. Patient’s caretaker should be prepared to assist the patient during this period. Patient and caretaker are trained accordingly. Physician or nurse may be contacted by phone at any time during this period whether a query or a complication. Check-up intervals will become less frequent as the patient starts to recover.

7. Post-Healing Long Term Monitoring
Once engraftment is complete and the healing process begins patient and caretaker will be informed on long-term transplant monitoring. Patient will receive in-depth evaluation and be given a report for the referring physician to monitor. The farewell meeting appointment to take place with the participation of the physician and nurse will provide comprehensive information to the patient and caretaker on to do’s, instances demanding notification, monitoring parameters, lifestyle, diet and exercises. Referring physician nonetheless performs long-term monitoring; the patient is generally called up for the first assessment in approximately 3 months. Long-term monitoring plan is developed specifically for the patient depending on medication, degree of immune system recovery, graft versus host disease and other complications that may develop.

Patients are also called to participate a vaccination programme at 12 and 24 months after engraftment.

Why Anadolu?

At Anadolu Medical Center’s modern and tranquil atmosphere our internationally renowned and experienced team prepares personalized treatments for our patients, which makes a difference to them and their families.

Bone Marrow (Stem Cell) Inpatient clinic features 22 beds on two levels. There is a special divide section at the entrance of each patient room creating a special section between the room and corridor. All staff of the BMU and (enter) pass to the patient rooms through this special zone, which purifies the individual from potential imported infections. This system significantly minimises risk of patient contact with such infections

Our spacious rooms feature special hepafilters and are designed to provide the patient psychological and mental comfort during their stay. Hepafilters are also installed in wards giving the patient the freedom to walk outside his or her room. Besides a personal music system, cable TV and wireless internet each patient room includes a specially designed orthopaedic bed.

At first application transplant candidate patients are requested to provide all past medical records, laboratory results, screening and pathology reports. In the next stage patients will be asked to provide a detailed background story, which is followed by an in-depth physical examination. The decision for transplant is given only after specialists evaluate benefits of treatment that will offer to the patient.

Our department employs state-of-the art diagnostic and treatment technology to surgically treat cardiovascular and lung diseases. Its patients range from newborns to adults.

  • To improve the quality of life, offering world-class health service,
  • Is an Institution pioneering in the field of strategic business partnerships and is affiliated with Johns Hopkins Medicine,
  • Offering expert staff, a patient-centered approach and successful medical practices,
  • Raises the bar in Turkey using cutting edge technology,
  • Health services provided by qualified medical personnel approved by international authorities,
  • Is a senior in the field of Oncology with its Bone Marrow Transplant Center,
  • Treating patients from around the world,
  • Offering patient's families comfortable accomodation with its on campur hotel,
  • Improving an organization Constantly improving itself and involved with corporate social responsibility projects.

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Cayirova Mh., Merkezi Hastanesi


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