Muscular dystrophies are a group of genetic diseases that affect skeletal muscles and often also heart muscle. The symptoms include muscle weakness and progressive muscle wasting.
Duchenne muscular dystrophy (DMD) is the most common and very severe form of the disease. It is caused by a genetic fault that prevents the production of a protein called dystrophin. Without dystrophin, muscles are fragile and are easily damaged. Over time so much damage builds up that the body can’t repair it and muscles waste away, causing progressive disability in patients.
In patients with a genetic disease like muscular dystrophy, stem cell therapy is a very attractive option because injection with a specific type of “stem cell” that can make muscle and express the missing protein has the potential to repair abnormal muscle function.
Mexico City, Mexico
|Muscular Dystrophy Stem Cell Treatment||$6,500|
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|Muscular Dystrophy Stem Cell Treatment||$10,000|
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|Muscular Dystrophy Stem Cell Treatment||$15,650|
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|Muscular Dystrophy Stem Cell Treatment||$11,000|
|Muscular Dystrophy Stem Cell Treatment||$11,642|
Producing healthy muscle fibers with the help of:
Reducing inflammation with the help of:
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Muscular dystrophies are a gathering of hereditary diseases that influence skeletal muscles and frequently likewise heart muscle. The side effects include muscle shortcoming and moderate muscle wasting. Duchenne muscular dystrophy (DMD) is the most well-known and extremely serious type of disease. It is brought about by a hereditary shortcoming that forestalls the creation of a protein called dystrophin. Without dystrophin, muscles are delicate and are handily damaged. After some time such a lot of damage develops that the body can't repair it and muscles die, causing moderate disability in patients.
Most of a muscle is shaped from heaps of muscle fibers, long cells containing numerous cores; however, muscles likewise contain numerous different kinds of cells, including stem cells. Stem cells are essential for the body's inbuilt repair system. They can create begetter cells and furthermore make duplicates of themselves. Skeletal muscles contain a sort of stem cell called satellite cells. At the point when muscle fibers are damaged, they convey substance messages to satellite cells telling them to shape new muscle fibers or to combine with existing fibers to repair the damage. Simultaneously some satellite cells duplicate themselves to guarantee sufficient stem cells are accessible to continue to repair and supplant muscle fibers later on.
Scientists believe that because the muscles are continually damaged in DMD the repair trouble set on satellite cells is enormous to the point that they become depleted and lose their capacity to duplicate themselves. Satellite cells are fundamental for muscle repair so as the number of these cells diminishes, the muscle becomes less and less ready to repair itself. Instead, damaged muscle fibers are supplanted by fat cells and scar tissue, weakening the muscle until it can presently don't work adequately.
Currently, there is no definitive remedy for DMD. Medicines intend to reinforce patients' muscles and decrease a portion of the manifestations of the disease. Steroids are routinely used to dial back muscle wasting yet they have many aftereffects, including weakening of bones leading to osteoporosis, hypertension, and deferred development. Physiotherapy may to some degree help to maintain muscle strength and adaptability. Researchers are hoping that, later on, they might be ready to repair or supplant damaged muscle fibers using various procedures, including transplantation of dystrophin-producing cells to reestablish or if nothing else safeguard muscle work.
There are a number of various kinds of stem cells that scientists think might be utilized in various ways of developing medicines for muscular dystrophy. The main stem-cell-based methodologies currently being investigated are:
Producing healthy muscle fibers: Scientists trust that, if stem cells without the hereditary deformity that causes DMD can be conveyed to patients' muscles, they might create working muscle fibers to supplant the patient's damaged ones.
Reducing inflammation: In muscular dystrophy damaged muscles become extremely inflamed. This inflammation speeds up muscle degeneration. Scientists believe certain sorts of stem cells may deliver synthetic compounds that lessen inflammation, slowing the advancement of the disease.
Besides stem cells, other restorative methodologies like quality treatment or little atom drugs for repairing the damaged quality are being tried in patients and in pre-clinical models. Future treatments are probably going to utilize a combination of more than one of these methodologies. Scientists are additionally studying the job of stem cells in the maintenance and repair of healthy muscles in request to comprehend in more detail what turns out badly in muscular dystrophy and how the issue could be remedied.
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