Beijing Bioocus Medical Group

Beijing Bioocus: Leading Biological Medical Center in Beijing, China

Fighting sickness can be really hard, but the innovative treatments (CAR-T Therapy, Tils therapy, NK cells therapy, and gene therapy) in Beijing, China by Bioocus International Medical Center is giving people hope with new ways to help the body fight back.  

BIOOCUS Medical Group is committed to advancing the research and development of cellular immunotherapies, offering innovative solutions for refractory diseases. As a leading medical group in China, we integrate the entire value chain with a cutting-edge research center, GMP-certified facilities, a CDMO platform, and comprehensive technology transfer capabilities.

With multiple CGT centers across the country, we provide specialized, high-quality treatment solutions to patients. We collaborate with top universities, research institutes, and over 20 leading hospitals worldwide to deliver transformative therapies.

Our mission is to expand access to breakthrough gene and cellular therapies, ensuring that patients receive the most advanced and effective life-saving treatments available.

International Patient Data and Services

• International Patient Services: 
End-to-end support from consultation to hospitalization, including a streamlined flowchart for patient guidance.

•  Strategic Partnerships: 
Collaborations with 48 top-tier hospitals across China and regional offices in Hong Kong, South Korea, India, Pakistan, the Middle East, Mongolia, Egypt, and South Africa. Partnerships with health authorities and embassies further enhance global outreach.

International Treatment Process

• Online Consultation & Case Evaluation
Patients engage with multilingual medical coordinators via website or hotline for personalized consultation.
Preliminary treatment plans, expert online assessments, and remote consultations are arranged.

• Hospital Admission & Visa Assistance
Medical coordinators schedule treatment timelines and assist with visas, flights, and accommodations.

• Hospitalization & Treatment
24/7 airport pickup and dedicated multilingual service coordinators provide full language and logistical support. Post-admission, comprehensive diagnostics confirm final treatment protocols.

• Post-Treatment Follow-Up
Tailored rehabilitation guidance, long-term monitoring, and telemedicine ensure continuity of care.

1. CAR-T Center in Beijing BIOOCUS Medical Group

CAR-T Therapy, short for Chimeric Antigen Receptor T-Cell Immunotherapy, is an advanced gene therapy method that involves genetically modifying a patient's own T cells to target and destroy cancer cells. Unlike traditional medications, CAR-T therapy is tailored to each patient and requires collecting T cells from the patient's blood before reinfusing them back into the body after genetic engineering.

Indications of CAR-T

• B-cell acute lymphoblastic leukemia

• Multiple myeloma

• Chronic lymphocytic leukemia

• Non-Hodgkin lymphoma

• Diffuse large B-cell lymphoma

• SLE?Systemic Lupus Erythematosus?

• Myasthenia gravis

• Other autoimmune diseases

Excellent CAR-T clinical performance

Our advantages:

1. Personalized Treatment: Each CAR-T therapy is customized to the patient, ensuring highly targeted and effective treatment outcomes.

2. Diverse Targeting Options: With a wide range of target antigens, including CD7, CD19, CD20, CD22, and BCMA, our CAR-T products offer unparalleled versatility in treating various hematological malignancies and autoimmune diseases.

3. Proven Clinical Success: Our CAR-T therapies have demonstrated exceptional effectiveness across numerous clinical cases, with impressive remission rates and safety profiles, reinforcing our position as a leader in immunotherapy.

4.  High Cost-Effectiveness: We offer a competitive edge with superior quality treatments at more accessible pricing compared to other CAR-T products on the market.

5. Cutting-Edge Technology: Leveraging the latest advancements in genetic engineering, our CAR-T therapies embody the future of cancer and autoimmune disease treatment.

6. Expert Clinical Support: Our experienced team of clinicians and researchers provides comprehensive care from initial consultation through therapy administration and follow-up.

CAR-T cells are now widely recognized for their efficacy in patients who have not responded to traditional treatments like chemotherapy or bone marrow transplantation. The global medical community acknowledges the groundbreaking potential of CAR-T therapy in transforming patient outcomes.

2. TIL Therapy center in Beijing BIOOCUS Medical Group 

TILs therapy involves extracting tumor-infiltrating lymphocytes (TILs), which are the most precise natural anti-tumor immune cells in the patient's body, from a tumor and cultivating them in large numbers in a lab. These activated TILs are then reintroduced into the patient's body to bolster the immune system's ability to target and kill cancer cells. TILs work by recognizing specific markers on cancer cells and launching an immune response against them, ultimately leading to tumor destruction.

What is Tils Therapy?

TILs therapy involves extracting tumor-infiltrating lymphocytes (TILs), which are the most precise natural anti-tumor immune cells in the patient's body, from a tumor and cultivating them in large numbers in a lab. These activated TILs are then reintroduced into the patient's body to bolster the immune system's ability to target and kill cancer cells. TILs work by recognizing specific markers on cancer cells and launching an immune response against them, ultimately leading to tumor destruction.

What’s the procedure of Tils Therapy?

Clinical Results Of Tils Therapy

Based on our clinical treatment results, the overall efficacy of TILs monotherapy reaches as high as 40%, making it the most effective tumor treatment method apart from surgery currently available.Bioocus tailors comprehensive treatment plan for each individual patient. One or several therapies will be combined with Tils therapy, which will increase the overall effective rate to more than 80%. The combined therapy aims to reduce the tumor load in the short term, and tils provide an opportunity for the patient to get cure in the long run.

Advantages Of Tils Therapy

High specificity: tumor specific T cells sensitized by tumor antigens, recognized by multiple TCRs

Strong tropism: high expression of chemokine receptors, strong tumor tropism, and faster action

Killing tumors: TILs are activated and amplified to 109-1011, and residual cancer cells are cleared after surgery

Continuous effect: The proportion of memory T cells is high, and they can survive in the body for a long time and be continuously monitored

High safety: extraction, amplification, no rejection reaction, and SAE of TILs cells from patients themselves

Indications for Tils Therapy

• NSCLC(non-small cell lung cancer)

• Melanoma

• Breast Cancer

• Cervical Cancer

• Ovarian Cancer.

Can all patients successfully cultivate TILs?

Our independently developed TILs cultivation process achieves a success rate of ≥85%. With a normal tissue sample of ≥1cm3, billions of TILs can be cultivated, and the cells exhibit strong cytotoxic activity."

Side Effects Of TILs Therapy?

1.TILs are the patient's own cells, so there is no risk of rejection, ensuring high safety.

2. Adverse reactions: Fever is common (due to the release of cytokines during TILs cell-mediated tumor clearance, causing transient fever, usually requiring no specific treatment and resolving on its own).

3.Other adverse reactions reported in studies include thrombocytopenia, febrile neutropenia, hypertension, etc., mostly attributed to TILs in combination with other drugs such as pre-treatment chemotherapy (cyclophosphamide + fluorouracil), high-dose IL-2, PD-1 monoclonal antibodies, etc.

3. Gene Therapy Center in Beijing BIOOCUS Medical Group

1?Hemo-cel, a groundbreaking gene therapy offering new hope for patients suffering from sickle cell disease (SCD) and transfusion-dependent thalassemia (TDT)

What is Hemo-cel?

Hemo-cel is an advanced therapy that uses the patient’s own hematopoietic stem and progenitor cells (HSPCs), which are genetically modified to produce healthy hemoglobin. By correcting the faulty gene responsible for the blood disorder, Hemo-cel can dramatically improve patients' lives, potentially eliminating the need for regular blood transfusions and offering a lifelong solution.

How Does Hemo-cel Work?

The treatment process begins by collecting HSPCs from the patient’s blood. These cells are then enhanced outside the body using a lentiviral vector that introduces a modified β-globin gene. Once the cells are ready, they are reinfused back into the patient, where they begin to generate healthy red blood cells capable of producing functional hemoglobin. This process restores the balance between α-globin and β-globin chains in the blood, effectively reducing the symptoms of anemia and allowing the patient to achieve transfusion independence.

Proven Results

Clinical trials of Hemo-cel have shown remarkable success:

100% of patients in the trial achieved successful bone marrow engraftment.
Most patients became transfusion-independent within weeks after the therapy.
One patient has been transfusion-free for nearly four years without any significant side effects.
The therapy also helps alleviate iron overload, a common complication in TDT patients who undergo regular transfusions.

A Future without Transfusions

Hemo-cel offers a promising future for those affected by SCD and beta-thalassemia. Imagine a life free from constant blood transfusions, with the potential for a permanent cure. At BIOOCUS, we are committed to making this vision a reality through cutting-edge gene therapy solutions like Hemo-cel.

2?Nusinersen Sodium Injection: The Hope for Spinal Muscular Atrophy

Nusinersen Sodium Injection is a revolutionary treatment for Spinal Muscular Atrophy (SMA), a rare genetic neuromuscular disorder that causes motor neuron loss, leading to severe muscle atrophy and weakness. As the world’s first approved disease-modifying therapy for 5q SMA, it has transformed patient outcomes globally

How It Works?

Nusinersen Sodium is an antisense oligonucleotide (ASO) therapy that targets the SMN2 gene.

By modifying its splicing process, it boosts the production of functional SMN protein, essential for motor neuron survival and function.

The drug is administered directly into the cerebrospinal fluid via lumbar puncture, ensuring it reaches the affected areas effectively.

Clinical Benefits

SMA Type I:

Increases 2-year survival rates from a historical 50% to over 80%.
Enhances motor functions like independent sitting and head control.
Reduces dependency on ventilators.

SMA Type II and III:

Slows disease progression.
Maintains or improves limb mobility and respiratory function.
Pre-symptomatic treatment (e.g., in newborns) can lead to near-normal motor development.

Long-Term Impact:

Five-year follow-up data show stable motor function improvements with no significant decline.

Global Reach:

Since its FDA approval in 2016, over 100,000 patients across 60+ countries have benefited, covering all SMA types.

Evidence from Research
Clinical trials (e.g., EMBRACE, ENDEAR, CHERISH) involving 274 patients demonstrate significant improvements:

Motor milestone response: 51% better than control groups (p<0.00001).
HINE-2 score improvement: 26% better than controls (p<0.0003).
Studies in adolescents and adults also show enhanced motor function scores (e.g., HFMSE, RULM) after 26 months.

Highly Qualified Regenerative Medicine Specialists in Beijing, China

At Beijing Bioocus Biotech Limited, we have a team of very smart and caring doctors who work hard to help people feel better. These special doctors study how the body can heal itself and find new ways to help sick people get stronger. They use science and technology to create treatments that give hope to patients. Our doctors are always learning and discovering new things to make medicine better and help more people live healthier lives.

Dr. Zhong Dingsheng

Dr. Fu Rong

Dr. Shao Zonghong

Dr. Wang Yan

Dr. Xishan Hao

Dr. Jihui Hao

Dr. Yafei Wang

Dr. Xiangcheng Zhi

Dr. Peng Zhao

Testimonials of Transformation with Bioocus Biotech in Beijing, China

Dive into the heartfelt narratives of individuals whose lives have been transformed by the pioneering regenerative medicine therapies of Beijing Bioocus Biotech Limited. Across diverse backgrounds and medical conditions, these testimonials reveal the profound impact of Bioocus Biotech's innovative approaches, illuminating stories of resilience, hope, and newfound vitality. From regaining mobility to reclaiming quality of life, each testimonial embodies the power of scientific advancement fused with compassionate care. Experience the journey of transformation through the lens of those who have walked it, guided by the expertise and dedication of Beijing Bioocus Biotech Limited.

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Awards and Certificates Received by Beijing Bioocus International Medical Center

Beijing Bioocus International Medical Center is very proud to have won special awards and certificates from two big organizations in China. One is the China Association for Promotion of Health Science and Technology (CHSTPA), which is super important in the world of public health. It is well-known all over the country and helps improve healthcare. The other is the Cellular Immune Therapy Association (CITA), which is part of CHSTPA. CITA focuses on treatments that help the body's immune system fight diseases, like CAR-T therapy and stem cell therapy. Since CITA supports Beijing Bioocus Biotech Limited, it means the center is doing amazing work in helping patients get better with advanced medical treatments.

The Beijing Institute of Technology (BIT) is a very famous university in China. It started a long time ago and is known for being great in science and engineering. One of its most important departments is the School of Life Science, where scientists study medicine and biology to find new ways to help people stay healthy. This department gets a lot of money to do research and is one of the best in the country. BIT’s School of Life Science is working hard to discover new treatments and technologies that can make healthcare better for everyone.

Exploring Medical Tourism in Beijing, China: Biological Therapy

In Beijing, China, special medical treatments called biological therapy are helping many people feel better. These treatments use the body's own cells to heal different health problems, like brain diseases and aging. Beijing has some of the best hospitals and doctors who use the latest technology to help patients. That’s why people from all over the world come to Beijing to get these advanced treatments.

Top Attractions in Beijing, China

Getting Around Beijing

Traveling to and around Beijing is easy because the city has many transportation options. People from different countries can fly to Beijing Capital International Airport, which connects to major cities around the world. From the airport, visitors can take taxis, airport buses, or private cars to their hotels. Inside the city, there are buses, subways, and taxis that make it simple to go from one place to another. If someone wants to visit nearby cities, they can take high-speed trains that travel very fast.

A Journey of Improvement and Discovery