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Stem Cell treatment for Autism in Chihuahua, México by CMCells
According to the Centers for Disease Control, the prevalence of autism hovers around 60 in every 10000 children. Even though there is no defined gold standard approach, current interventions for autism can be divided into behavioral, nutritional and pharmacological.
The pathogenic mechanism of autism is not clearly understood and remains elusive. Nevertheless, two pathologies are commonly found within the autism patients: the first observation is an impaired central nervous system circulation and hypoperfusion to the brain, whereas the second observation is systemic T cell and B cell abnormalities as well as active neuroinflammatory processes in the brain. Based on the immunomodulatory properties of MSCs, therapies employing MSCs have been proposed to target the immune deregulation observed in autism. Basically, it is believed that MSCs are able to inhibit the release of pro-inflammatory cytokines and have strong immunosuppressive activity.
Autism spectrum disorders (ASDs) are characterized by core domains: persistent deficits in social communication and interaction; restricted, repetitive patterns of behavior, interests, or activities. ASDs comprise heterogeneous and complex neurodevelopmental pathologies with welldefined inflammatory conditions and immune system dysfunction. Due to neurobiologic changes underlying ASD development, cell-based therapies have been proposed and applied to ASDs. Indeed, stem cells show specific immunologic properties, which make them promising candidates in ASD treatment. This comprehensive up-to-date review focuses on ASD cellular/molecular abnormalities, potentially useful stem cell types, animal models, and current clinical trials on the use of stem cells in treating autism. Limitations are also discussed.