NeuroGen Brain and Spine Institute

Special Muscular Dystrophy Treatment Package In Mumbai, India

Sector 40, Plot No. 19, Opposite Konkan Rail Vihar,Near Seawood Station, Palm Beach Road,
Seawood (W) New Mumbai,, 4000706 Mumbai, India

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Treatment :Stem Cell Therapy

By : NeuroGen Brain and Spine Institute

Location : Sector 40, Plot No. 19, Opposite Konkan Rail Vihar,Near Seawood Station, Palm Beach Road,
Seawood (W) New Mumbai, Mumbai, India 4000706

Focus Area: NeuroGen Brain and Spine Institute | Mumbai | India | Neurology,Rehabilitation,Stem Cell Therapy

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The term Muscular Dystrophy(MD) refers to a group of genetic diseases marked by progressive weakness and degeneration of the skeletal or voluntary muscles, which control movement. The muscles of the heart and some other involuntary muscles are also affected in some forms of muscular dystrophy, and a few forms involve other organs as well. It is a term used to describe a number of inherited disorders characterized by progressive weakness and wasting of the muscles. The most common and severe type is Ducchenne’s muscular dystrophy , which is a X-linked recessive disorder, affecting 1 in 3,500 live male births . DMD children show early symptoms of muscle degeneration, frequently develop contractures, and lose the ability to walk between 6 and 12 years of age.These disorders vary in their age of onset, in severity and in the pattern of which muscles are affected. All forms of muscular dystrophy, however, grow worse as muscles progressively degenerate. In some types of muscular dystrophy, the heart, the gastrointestinal system, endocrine glands, the skin, the eyes and other organs may be affected. MD weakens muscles over time, so children, teens, and adults who have the disease can gradually lose the ability to do things like walking or sitting up.

The muscular dystrophy is diagnosed by muscle biopsy, DNA testing, electromyogram (EMG) and nerve conduction velocity (NCV). Blood enzyme tests are helpful because degenerating muscle become "leaky". They leak enzymes, which can then be detected in the blood. Presence of these enzymes in the blood at higher than normal levels is a sign of muscular dystrophy. One such enzyme is Creatine kinase, or CK. The CK level is elevated in many forms of muscular dystrophy, some forms resulting in a higher level than others.

The major forms of muscular dystrophy are myotonic, Duchenne, Becker, limb-girdle, facioscapulo-humeral, congenital, oculo-pharangeal, distal and Emery-Dreifuss. Some of these names are based on the locations of affected muscles. For example, "facioscapulo-humeral" refers to the muscles that move the face, scapula (shoulder blade) and humerus (upper arm bone). Others are based on the type of muscle problem involved ("myotonic" means difficulty relaxing muscles), the age of onset of the disease (as in "congenital," or birth-onset, dystrophy), or the doctors who first described the disease (Duchenne, Becker, Emery and Dreifuss are doctors’ names). Forms of muscular dystrophy differ in severity, age of onset, muscle first and most often affected, the rate at which symptoms progress, and the way the disorders are inherited.

Duchenne muscular dystrophy (DMD) is the most common childhood muscular dystrophy and results from mutations in the dystrophin gene. Itis characterized by (i) Onset of muscle weakness usually before 4 years of age, (ii) Selective muscle involvement of pelvic and pectoral girdles, (iii) Hypertrophy of the calves muscle, (iv) grossly elevated serum C K levels and (v) Relentlessly progressive weakness of muscle, leading to inability to work within 10 years of onset and later to contractures and thoracic deformity. There is no specific cure in any system of medicine and the death usually occurs before the age of 20 years caused by respiratory failure or less frequently by cardiac involvement.(4) New and promising experimental strategies to address DMD have been developed over the last few years and some of them are in or are approaching clinical trials. Different therapeutic options are being investigated, ranging from mutation-specific treatments, including nonsense codon suppressors and exon skipping, to gene therapy using viral and nonviral vectors and cell-based approaches.

Becker muscular dystrophy (BMD) was initially described by Becker and Kiener in 1955. The signs, symptoms and the course of Becker muscular dystrophy (BMD) are similar to those of Duchenne but generally appear later and progress more slowly. BMD is generally milder than DMD. The clinical distinction between the 2 conditions is relatively easy because (i) less severe muscle weakness is observed in patients with BMD and (ii) affected maternal uncles with BMD continue to be ambulatory after age 15-20 years. Accuracy of diagnosis has been refined with the recognition of the dystrophin gene defects and with dystrophin staining of muscle biopsy specimens. The progression is typically slower, with the ability to walk usually preserved in to the 30s. The severity of the disease varies, and boys and men with Becker dystrophy have a longer life expectancy than those with Duchenne. The progression of weakness depends on how much dystrophin is made and how well it functions in the muscles.

Limb-girdle muscular dystrophies (LGMD) are neuromuscular disorders characterized by proximal muscular weakness of the pelvic and shoulder girdles and a variable progression with symptoms, ranging from very severe to mild (7), (4). The onset of Limb Girdle Muscular dystrophy (L G M D) is generally in adolescence or early adulthood. In most common forms, L G M D causes progressive weakness that starts in the hips and moves to the shoulders. The weakness progresses to include the arms and legs. Within 20 years of onset, walking is difficult.

There is no specific treatment to cure or halt MD. Physical therapy, exercise, orthopedic appliances (such as braces and wheelchairs), or corrective orthopedic surgery may help to preserve muscle function and prevent joint contractures as much as possible and improve quality of life. Steroids have been used to slow disease progression, but do not affect the final outcome. Identification of the specific genes responsible for the various types of MD has led to extensive research on gene and molecular therapy, but all such treatments are still experimental.

Several different therapeutic options are under investigation, including adult-derived stem cell transplantation. Results show that the healthy stem cells provide an effective source of immediately available muscle regenerative cells as well as a reserve pool that can maintain muscle regenerative activity in response to future challenges.

Bone marrow derived stem cells are used from the patient’s own body and injected into the spine and weak muscles in order to boost muscle regeneration. This treatment is carried out in conjunction with rehabilitation at NeuroGen Brain and Spine Institute.

 

  • Airports pick up and drop via ambulance/car.
  • Stay at the hospital in a deluxe room (care taker accommodated along with patient).
  • Pre-operative investigations as required, (MRI/PET CT scans, EMG & NCV and blood tests).
  • Stem Cell Therapy.
  • A comprehensive rehabilitation program which includes physiotherapy, occupational therapy, speech therapy, psychological counseling, genitourinary rehabilitation, sexual rehabilitation.
  • Specialty consultations during the stay.
  • Nursing care.
  • Vegetarian food for the patient and one attendant.
  • The above packages are at a fixed cost
  • Payment Mode: 100% payment through SWIFT transfer before admission.

At NeuroGen Brain and Spine Institute we provide a ray of hope to people who have none and thereby increase the quality of life.

NeuroGen Brain and Spine Institute is an institution which not just wants to give treatment to the patients but also take into consideration the overall well being of the patient.

The NeuroGen Brain & Spine Institute has been set up to help such patients get relief from their symptoms and physical disabilities using the safest and most effective available treatments and technologies from the field of the Neurosciences & Regenerative medicine in a professional & scientific as well as a holistic & caring manner.

 

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Sector 40, Plot No. 19, Opposite Konkan Rail Vihar,Near Seawood Station, Palm Beach Road,
Seawood (W) New Mumbai,

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